Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by severely pruritic skin nodules.
Monoclonal antibody inhibiting signaling through oncostatin M receptor beta (OSMRβ).
Vixarelimab inhibits signaling of interleukin-31 (IL-31) and oncostatin M (OSM), 2 key cytokines implicated in inflammation, pruritus, and fibrosis.
We estimate that there are approximately 300,000 patients with PN in the United States.
Breakthrough Therapy designation granted by the US Food and Drug Administration (FDA) to vixarelimab for the treatment of pruritus associated with prurigo nodularis.
Studies link many pruritic and inflammatory diseases to both IL-31 and OSM via signaling through OSMRβ. By targeting both pathways simultaneously, vixarelimab may disrupt the pathologic cycle in patients afflicted by a variety of pruritic diseases.
We are conducting a dose-ranging Ph2b trial of vixarelimab in patients with prurigo nodularis.
In 2020, we reported data from a randomized, double-blind, placebo-controlled Phase 2a clinical trial of vixarelimab in patients with prurigo nodularis.
We are not aware of any current therapies approved by the FDA for the treatment of PN.